今月の研究者

星野 純一

星野 純一

 私は、横浜市立大学を卒業後、一貫して虎の門病院にて臨床に従事して参りました。(幸か不幸か?)生粋の虎っ子です。臨床医として10年が過ぎ、既存のエビデンスを超えた実臨床の多彩さ・奥深さを経験するにつれ、素晴らしい上司・同僚に恵まれたこともあり、自ら臨床研究を行いエビデンスを発信していく重要性を認識。今後の臨床研究の幅を広げる道を模索していたところ、幸い共済医学会より海外留学の機会を頂きました。統計・疫学の本場である米国UCLA大学院へ留学し、疫学の修士号(Master of public health, Epidemiology)を取得。更にUCLA内の臨床系研究室にて大規模データを用いた臨床研究や国際共同研究に」従事して参りました。
 2012年に帰国してからは、日常臨床を行いながら医局データベースを整備。さらに情熱溢れる若手医師達とともに、多発性嚢胞腎・IgA腎症・糖尿病性腎症・アミロイドーシスを中心とした腎臓・膠原病に関する臨床研究を積極的に行っております。そのためか医局の英語論文数は順調に増加。また糖尿病性腎症やIgA腎症に関する多施設共同研究を推進し、他大学研究者との交流も深めています。
 医学は日進月歩です。遺伝子技術やiPS細胞などの基礎医学系進歩は有名ですが、臨床研究でも同様なことがいえます。特にコンピュータの発達に伴ったここ10年の近代疫学統計手法の進歩は著しく、近年の臨床系トップジャーナルには傾向スコアや周辺構造モデルなどの近代疫学用語が頻繁に見受けられるようになりました。
 冲中記念成人病研究所の理念「成人病に関する臨床的・基礎的研究をもって医療水準の向上に寄与すること」を実現するためには、斬新な発想と共に、ある程度の近代疫学・統計知識の理解が必要不可欠です。研究デザインや疫学・統計に関して皆さまの臨床研究に少しでもお役に立てるよう努力していきたいと思いますので、よろしくお願い申し上げます。

発表・論文

2014年

1. Hoshino, J, Suwabe, T, Hayami N, Sumida, K, Mise, K, Kawada M, Imafuku A, Hiramatsu, R, Hasegawa, E, Yamanouchi, M, Sawa, N, Takei, R, Takaichi, K, Ubara Y: Survival after arterial embolization therapy in patients with polycystic kidney and liver disease. J Nephrol 2014 [in press]

2. Hoshino J, Ubara Y, Suwabe T, Sumida K, Hayami N, Mise K, Hiramatsu R, Hasegawa E, Yamanouchi M, Sawa N, Takei R, Takaichi K: Intravascular embolization therapy in patients with enlarged polycystic liver. Am J Kidney Dis 63:937-944, 2014.

3. Hoshino J, Yamagata K, Nishi S, Masakane I, Iseki K, Tsubakihara Y. Carpal tunnel surgery as proxy for dialysis-related amyloidosis: results from the Japanese society for dialysis therapy. Am J Nephrol 39:449-58, 2014.

4. Hoshino J, Everly MJ, Kaneku H, Ubara Y, Takaichi K, Terasaki PI. Impact of presence and duration of donor-specific antibodies on renal function. Transplant Proc. 46:75-80, 2014.

5. Mise, K, Hoshino, J, Ueno, T, Sumida, K, Hiramatsu, R, Hasegawa, E, Yamanouchi, M, Hayami, N, Suwabe, T, Sawa, N, Fujii, T, Hara, S, Ohashi, K, Takaichi, K, Ubara, Y: Clinical and pathological predictors of estimated GFR decline in patients with type 2 diabetes and overt proteinuric diabetic nephropathy. Diabetes/metabolism research and reviews, 2014 [in press].

6. Mise K, Hoshino J, Sumida K, Hayami N, Suwabe T, Hiramatsu R, Hasegawa E, Sawa N, Fujii T, Ohashi K, Takaichi K, Ubara Y. Impact of tubulointerstitial lesions on anemia in patients with biopsy-proven diabetic nephropathy. Diabetic Medicine. 2014 [in press]

7. Mise K, Hoshino J, Sumida K, Hayami N, Suwabe T, Hiramatsu R, Hasegawa E, Sawa N, Fujii T, Ohashi K, Takaichi K, Ubara Y. Clinical implications of linear immunofluorescent staining for immunoglobulin G in patients with diabetic nephropathy. Diabetes Res Clin Pract 2014 [in press]

8. Endo A, Hoshino J, Suwabe T, Sumida K, Mise K, Hiramatsu R, Hasegawa E, Yamanouchi M, Hayami N, Sawa N, Takaichi K, Ohashi K, Fujii T, Ubara Y. Significance of small renal artery lesions in patients with antineutrophil cytoplasmic antibody-associated glomerulonephritis. J Rheumatol. 41:1140-6, 2014.

9. Mise K, Hoshino J, Ubara Y, Sumida K, Hiramatsu R, Hasegawa E, Yamanouchi M, Hayami N, Suwabe T, Sawa N, Fujii T, Ohashi K, Takaichi K. Renal prognosis of patients diagnosed with diabetic nephropathy 10 years after renal biopsy. Nephrol Dial Transplant 29: 109-18, 2014.

10. Sumida, K, Ubara, Y, Hoshino, J, Hayami, N, Suwabe, T, Hiramatsu, R, Hasegawa, E, Yamanouchi, M, Sawa, N, Fujii, T, Takaichi, K: Bone histomorphometry in a long-term hemodialysis patient with hypoparathyroidism and sarcoidosis. Osteoporosis international, 2014 [in press].

11. Hattori Y, Hoshino J, Suwabe T, Sumida K, Mise K, Hayami N, Sawa N, Takaichi K, Ubara Y. Umbilical hernia in autosomal dominant polycystic kidney disease. Clin Exp Nephrol. 2014 Jan 10 [Epub ahead of print]

12. Suwabe T, Hoshino J, Sumida K, Mise K, Hayami N, Takaichi K, Ubara Y. Adynamic bone disease: a 14-year case report. Kidney Int, 85:217, 2014.

13. Iijima, T, Suwabe, T, Sumida, K, Hayami, N, Hiramatsu, R, Hasegawa, E, Yamanouchi, M, Hoshino, J, Sawa, N, Takaichi, K, Oohashi, K, Fujii, T, Ubara, Y: Tocilizumab improves systemic rheumatoid vasculitis with necrotizing crescentic glomerulonephritis. Mod Rheumatol, 2014 Feb 18. [Epub ahead of print].

14. Kaseda K, Marui Y, Suwabe T, Hoshino J, Sumida K, Hayami N, Mise K, Tanaka K, Takaichi K, Tomikawa S, Fujii T, Ohashi K, Ubara Y. Kidney transplantation for a patient with refractory childhood-onset ANCA-associated vasculitis. Mod Rheumatol 2014 Mar 19. [Epub ahead of print]

15. Yamanouchi M, Ubara Y, Mise K, Hayami N, Hiramatsu R, Sumida K, Suwabe T, Hasegawa E, Hoshino J, Sawa N, Takemoto F, Takaichi K. Hemodialysis without anticoagulation for a patient with chronic disseminated intravascular coagulation. Case Rep Neohrol Urol. 18;4:25-30, 2014.

2013年

1. Hoshino, J, Molnar, MZ, Yamagata, K, Ubara, Y, Takaichi, K, Kovesdy, CP, Kamyar, K-Z: Developing an A1c based equation to estimate blood glucose in maintenance hemodialysis patients. Diabetes Care, 36: 922-927, 2013.

2. Hoshino, J, Mehrotra, R, Rhee, CM, Yamagata, K, Ubara, Y, Takaichi, K, Kovesdy, CP, Molnar, MZ, Kalantar-Zadeh, K: Using Hemoglobin A1c to Derive Mean Blood Glucose in Peritoneal Dialysis Patients. Am J Nephrol, 37: 413-420, 2013.

3. Hiramatsu, R, Hoshino, J, Suwabe, T, Sumida, K, Hasegawa, E, Yamanouchi, M, Hayami, N, Sawa, N, Takaichi, K, Ohashi, K, Fujii, T, Ubara, Y: Membranoproliferative glomerulonephritis and circulating cryoglobulins. Clin Exp Nephrol, 2013.

4. Suwabe T, Ubara Y, Mise K, Kawada M, Hamanoue S, Sumida K, Hayami N, Hoshino J, Hiramatsu R, Yamanouchi M, Hasegawa E, Sawa N, Takaichi K. Quality of life of patients with ADPKD-Toranomon PKD QOL study: cross-sectional study. BMC Nephrol. 27;14:179, 2013.

5. Yamanouchi, M, Ubara, Y, Hayami, N, Suwabe, T, Hiramatsu, R, Sumida, K, Hasegawa, E, Hoshino, J, Sawa, N, Tanaka, K, Marui, Y, Nakamura, M, Tomikawa, S, Takaichi, K: Bone mineral density 5 years after parathyroidectomy in hemodialysis patients with secondary hyperparathyroidism. Clin Nephrol, 79: 380-386, 2013.

6. Nonaka, K, Ubara, Y, Sumida, K, Hiramatsu, R, Hasegawa, E, Yamanouchi, M, Hayami, N, Suwabe, T, Hoshino, J, Sawa, N, Takaichi, K, Kuroda, Y, Oohashi, K: Clinical and pathological evaluation of hypertensive emergency-related nephropathy. Intern Med, 52: 45-53, 2013.

7. Sumida, K, Ubara, Y, Suwabe, T, Hayami, N, Hiramatsu, R, Hasegawa, E, Yamanouchi, M, Hoshino, J, Sawa, N, Takaichi, K: Adalimumab treatment in patients of rheumatoid arthritis with renal insufficiency. Arthritis Care Res (Hoboken) 65:471-475, 2013.

8. Sawa, N, Ubara, Y, Sumida, K, Hiramatsu, R, Hasegawa, E, Yamanouchi, M, Hoshino, J, Suwabe, T, Uchida, N, Wake, A, Taniguchi, S, Takaichi, K: Direct hemoperfusion with a polymyxin B column versus vasopressin for gram negative septic shock: a matched cohort study of the effect on survival. Clin Nephrol, 79:463-70, 2013.

9. Tsuchiya, Y, Hoshino, J, Suwabe, T, Sumida, K, Hiramatsu, R, Mise K, Hasegawa, E, Yamanouchi, M, Hayami, N, Sawa, N, Arizono K, Hara S, Takaichi, K, Fujii T, Ubara, Y. Variegate porphyria complicated by systemic AA amyloidosis: a case report. Amyloid, 20:272-4, 2013.

10. Tsuchiya, Y, Ubara, Y, Suwabe, T, Nomura, K, Sumida, K, Hiramatsu, R, Hoshino, J, Hasegawa, E, Yamanouchi, M, Hayami, N, Sawa, N, Takaichi, K, Oohashi, K: AA-amyloidosis in autosomal dominant polycystic kidney disease caused by chronic cyst infections lasting for 30 years. Intern Med, 52: 791-794, 2013.

11. Sumida, K, Ubara, Y, Hoshino, J, Hayami, N, Suwabe, T, Hiramatsu, R, Hasegawa, E, Yamanouchi, M, Sawa, N, Takaichi, K, Ohashi, K: Myeloperoxidase-antineutrophil cytoplasmic antibody-associated crescentic glomerulonephritis in autosomal dominant polycystic kidney disease. BMC nephrology, 14: 94, 2013.

12. Mise, K, Ubara, Y, Sumida, K, Hiramatsu, R, Hasegawa, E, Yamanouchi, M, Hayami, N, Suwabe, T, Hoshino, J, Sawa, N, Hashimoto, M, Fujii, T, Sasano, H, Takaichi, K: Cushing's syndrome after hemodialysis for 21 years. The Journal of clinical endocrinology and metabolism, 98: 13-19, 2013.

13. Mise, K, Ubara, Y, Matsumoto, M, Sumida, K, Hiramatsu, R, Hasegawa, E, Yamanouchi, M, Hayami, N, Suwabe, T, Hoshino, J, Sawa, N, Ohashi, K, Kokame, K, Miyata, T, Fujimura, Y, Takaichi, K: Long term follow up of congenital thrombotic thrombocytopenic purpura (Upshaw-Schulman syndrome) on hemodialysis for 19 years: a case report. BMC nephrology, 14: 156, 2013.

14. Imafuku, A, Suwabe, T, Hasegawa, E, Mise, K, Sumida, K, Hiramatsu, R, Yamanouchi, M, Hayami, N, Hoshino, J, Sawa, N, Oohashi, K, Fujii, T, Okubo, M, Takaichi, K, Oga, T, Ubara, Y: Castleman's Disease Accompanied by Hypolipidemic Cerebral Hemorrhage and Nephrosclerosis. Intern Med, 52: 1611-1616, 2013.

15. Hiramatsu R, Ubara Y, Suwabe T, Hoshino J, Sumida K, Hasegawa E, Yamanouchi M, Hayami N, Sawa N, Takaichi K. Cartilage-dependent subchondral ossification in rheumatoid arthritis. J Rheumatol, 40: 1923-4, 2013.

16. Hiramatsu, R, Ubara, Y, Suwabe, T, Hoshino, J, Sumida, K, Hasegawa, E, Yamanouchi, M, Hayami, N, Sawa, N, Takaichi, K: Bone histomorphometric analysis in a patient with anorexia nervosa. Bone, 56: 77-82, 2013.

17. Hiramatsu R, Ubara Y, Hayami N, Yamanouchi M, Hasegawa E, Sumida K, Suwabe T, Hoshino J, Sawa N, Amizuka N, Takaichi K. Occurrence of new bone-like tissue formation in uremic tumoral calcinosis. Bone, 52:684, 2013.

2012年

1. Hoshino, J, Kaneku, H, Everly, MJ, Greenland, S, Terasaki, PI: Using donor-specific antibodies to monitor the need for immunosuppression. Transplantation, 93: 1173-1178, 2012.

2. Yamakoshi, S, Ubara, Y, Suwabe, T, Hiramatsu, R, Yamanouchi, M, Hayami, N, Sumida, K, Hasegawa, E, Hoshino, J, Sawa, N, Takaichi, K, Kawabata, M: Transcatheter renal artery embolization improves lung function in patients with autosomal dominant polycystic kidney disease on hemodialysis. Clin Exp Nephrol, 16: 773-778, 2012.

3. Suwabe, T, Ubara, Y, Sumida, K, Hayami, N, Hiramatsu, R, Yamanouchi, M, Hasegawa, E, Hoshino, J, Sawa, N, Saitoh, S, Okuda, I, Takaichi, K: Clinical features of cyst infection and hemorrhage in ADPKD: new diagnostic criteria. Clin Exp Nephrol, 16: 892-902, 2012.

4. Sumida, K, Ubara, Y, Nomura, K, Hoshino, J, Suwabe, T, Hiramatsu, R, Hasegawa, E, Hayami, N, Yamanouchi, M, Sawa, N, Takemoto, F, Takaichi, K, Ohashi, K: ANCA-associated crescentic glomerulonephritis with immune complex deposits. Clin Nephrol, 77: 454-460, 2012.

5. Molnar, MZ, Streja, E, Kovesdy, CP, Hoshino, J, Hatamizadeh, P, Glassock, RJ, Ojo, AO, Kalantar-Zadeh, K: Estimated glomerular filtration rate at reinitiation of dialysis and mortality in failed kidney transplant recipients. Nephrol Dial Transplant, 27: 2913-2921, 2012.

6. Molnar, MZ, Kovesdy, CP, Rosivall, L, Bunnapradist, S, Hoshino, J, Streja, E, Krishnan, M, Kalantar-Zadeh, K: Associations of pre-transplant anemia management with post-transplant delayed graft function in kidney transplant recipients. Clin Transplant, 26: 782-791, 2012.

7. Nagasawa, M, Ubara, Y, Suwabe, T, Yamanouchi, M, Hayami, N, Sumida, K, Hattori, Y, Tsukamoto, M, Hiramatsu, E, Hasegawa, E, Hoshino, J, Sawa, N, Marui, Y, Nakamura, M, Tomikawa, S, Takaichi, K: Parathyroid hemorrhage occurring after administration of cinacalcet in a patient with secondary hyperparathyroidism. Intern Med, 51: 3401-3404, 2012.

8. Hirohama, D, Hoshino, J, Sumida, K, Hasegawa, E, Hiramatsu, R, Yamanouchi, M, Hayami, N, Suwabe, T, Sawa, N, Takemoto, F, Ubara, Y, Hara, S, Ohashi, K, Takaichi, K: Churg-strauss syndrome presenting with acute renal insufficiency accompanied by eosinophilic tubulointerstitial nephritis. Intern Med, 51: 1555-1560, 2012.

9. Hiramatsu, R, Ubara, Y, Suwabe, T, Sumida, K, Hayami, N, Yamanouchi, M, Mise, K, Hasegawa, E, Hoshino, J, Sawa, N, Takaichi, K: Osteomalacia and insufficiency fracture in a hemodialysis patient with autosomal dominant polycystic kidney disease. Intern Med, 51: 3277-3280, 2012.

10. Hattori, Y, Ubara, Y, Sumida, K, Hiramatsu, R, Hasegawa, E, Yamanouchi, M, Hayami, N, Suwabe, T, Hoshino, J, Sawa, N, Oohashi, K, Takaichi, K: Tocilizumab improves cardiac disease in a hemodialysis patient with AA amyloidosis secondary to rheumatoid arthritis. Amyloid, 19: 37-40, 2012.

11. Ayuzawa, N, Ubara, Y, Keiichi, S, Masayuki, Y, Hasegawa, E, Hiramatsu, E, Hayami, N, Suwabe, T, Hoshino, J, Sawa, N, Kawabata, M, Ohashi, K, Takaichi, K: Churg-Strauss syndrome with a clinical condition similar to IgG4-related kidney disease: a case report. Intern Med, 51: 1233-1238, 2012.

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