受賞

2011年

日本集中治療学会総会 若手奨励賞
Asian-Pacific Congress of Hypertension 2011　Young Investigator Award

2012年

第100回日本循環器学会中国・四国合同地方会 若手研究者奨励賞(YIA)
第225回日本循環器学会関東・甲信越地方会 若手研究者奨励賞(YIA) 優秀賞

2013年

2012年木曜カンファレランス　BEST PRESENTER
第2回臨床高血圧フォーラム Young Clinician Award 優秀賞
第2回日本心臓病財団・日循協・アストラゼネカ　臨床疫学研究助成
第230回日本循環器学会関東・甲信越地方会　若手研究者奨励賞(YIA)最優秀賞

2014年

第50回日本循環器病予防学会学術集会　若手研究者奨励賞(YIA)最優秀賞

2015年

第51回第50回日本循環器病予防学会学術集会　ポスター賞
Hypertension Research Award 優秀賞

2016年

国家公務員共済組合連合会　1種海外留学奨学金

2017年

APS (The American Physiological Society) Select Award
Publons Peer Review Awards 2017, the top 1 per cent of peer reviewers, in General
日本心臓病学会 Young Investigated Award 優秀賞
Karen L. Campbell, PhD, Travel Support Award to attend ASN (American Society of Nephrology) Kidney Week 2017

2018年

International Scholar Collaborative Opportunity for Research Exchange (iSCORE) Award (University of Colorado, Denver, and Anschutz Medical Campus)
Publons Peer Review Awards 2018 in Clinical Medicine and in Multidisciplinary
International Symposium on: Uric Acid and Cardiometabolic Disease, Faculty, 招聘講演

最近5年間の論文

Original Articles/ Review Articles
First or Corresponding Author (included equally contribution)

1. Kuwabara M, Chintaluru Y, Kanbay M, Niwa K, Hisatome I, Andres-Hernando A, Roncal-Jimenez C, Ohno M, Johnson RJ, Lanaspa MA. Fasting Blood Glucose is Predictive of Hypertension in a General Japanese Population. Journal of Hypertension. 2018 doi: 10.1097/HJH.0000000000001895

2. Jensen T, Niwa K, Hisatome I, Kanbay M, Andres-Hernando A, Roncal-Jimenez CA, Sato Y, Garcia G, Ohno M, Lanaspa MA, Johnson RJ, Kuwabara M. Increased Serum Uric Acid over five years is a Risk Factor for Developing Fatty Liver. Sci Rep. 2018:8(1):11735.

3. Kuwabara M*, Kuwabara R*, Niwa K, Hisatome I, Smits G, Roncal-Jimenez CA, MacLean PS, Yracheta JM, Ohno M, Lanaspa MA, Johnson RJ, Jalal DI. (*equally contributed) Different Risk for Hypertension, Diabetes, Dyslipidemia, and Hyperuricemia According to Level of Body Mass Index in Japanese and American Subjects. Nutrients. 2018:10(8):E1011

4. Kuwabara M, Yashiro M, Ae R, Yanagawa H, Nakamura Y. The Effects of Early Intravenous Immunoglobulin Therapy for Kawasaki Disease: The 22nd Nationwide Survey in Japan. Int J Cardiol. 2018:269:334-338.

5. Kuwabara M, Borghi C, Cicero AFG, Hisatome I, Niwa K, Ohno M, Johnson RJ, Lanaspa MA. Elevated serum uric acid increases risks for developing high LDL cholesterol and hypertriglyceridemia: A five-year cohort study in Japan. Int J Cardiol. 2018:261:183-188.

6. Lanaspa MA*, Kuwabara M*, Andres-Hernando A*, Li N, Cicerchi C, Jensen T, Orlicky DJ, Roncal-Jimenez CA, Ishimoto T, Nakagawa T, Rodriguez-Iturbe B, MacLean PS, Johnson RJ. (*equally contributed) High salt intake causes leptin resistance and obesity in mice by stimulating endogenous fructose production and metabolism. Proc Natl Acad Sci U S A. 2018:115(12):3138-3143.

7. Kuwabara M, Niwa K, Toyoda T, Shirai T, Tateno S, Ohuchi H, Tanaka Y, Ichida F, Fujisawa T, Akagi T, Mori Y; Research Committee of the Japanese Society of Pediatric Cardiology and Cardiac Surgery. Liver Cirrhosis and/or Hepatocellular Carcinoma Occurring Late After the Fontan Procedure - A Nationwide Survey in Japan. Circ J. 2018:82(4):1155-1160.

8. Kuwabara M, Hisatome I, Niwa K, Hara S, Roncal-Jimenez CA, Bjornstad P, Nakagawa T, Andres-Hernando A, Sato Y, Jensen T, Garcia G, Rodriguez-Iturbe B, Ohno M, Lanaspa MA, Johnson RJ. Uric acid is a strong risk marker for developing hypertension from prehypertension: a 5-year Japanese cohort study. Hypertension. 2018:71:78–86.

9. Kuwabara M, Niwa K, Yamada U, Ohta D. Low Body Mass Index Correlates with Low Left Ventricular Mass Index in Patients with Severe Anorexia Nervosa. Heart Vessels. 2018:33(1):89-93.

10. Kuwabara M, Kuwabara R, Hisatome I, Niwa K, Roncal-Jimenez CA, Bjornstad P, Andres-Hernando A, Sato Y, Jensen T, Garcia G, Ohno M, Hill JO, Lanaspa MA, Johnson RJ. “Metabolically Healthy” Obesity and Hyperuricemia Increase Risk for Hypertension and Diabetes: 5-year Japanese Cohort Study. Obesity (Silver Spring). 2017:25(11):1997-2008.

11. Kuwabara M, Niwa K, Ohtahara A, Hamada T, Miyazaki S, Mizuta E, Ogino K, Hisatome I. Prevalence and complications of hypouricemia in a general population: A large-scale cross-sectional study in Japan. PLoS One. 2017:12(4):e0176055.

12. Kuwabara M, Niwa K, Hisatome I, Nakagawa T, Roncal-Jimenez CA, Andres-Hernando A, Bjornstad P, Jensen T, Sato Y, Milagres T, Garcia G, Ohno M, Lanaspa MA, Johnson RJ. Asymptomatic Hyperuricemia without Comorbidities Predicts Cardiometabolic Diseases: 5-year Japanese Cohort Study. Hypertension. 2017:69(6):1036-1044.

13. Kuwabara M, Bjornstad P, Hisatome I, Niwa K, Roncal-Jimenez CA, Andres-Hernando A, Jensen T, Milagres T, Sato Y, Garcia G, Ohno M, Lanaspa MA, Johnson RJ. Elevated serum uric acid level predicts rapid decline in kidney function. Am J Nephrol. 2017:45(4):330-337.

14. Kuwabara M, Hisatome I, Roncal-Jimenez CA, Niwa K, Andres-Hernando A, Jensen T, Bjornstad P, Milagres T, Cicerchi C, Song Z, Garcia G, Sánchez-Lozada LG, Ohno M, Lanaspa MA, Johnson RJ. Increased Serum Sodium and Serum Osmolarity Are Independent Risk Factors for Developing Chronic Kidney Disease; 5 Year Cohort Study. PLoS One. 2017:12(1):e0169137.

15. Kuwabara M, Niwa K, Nishihara S, Nishi Y, Takahashi O, Kario K, Yamamoto K, Yamashita T, Hisatome I. Hyperuricemia is an independent competing risk factor for atrial fibrillation. Int J Cardiol. 2017:231:137-142.

16. Kuwabara M, Motoki Y, Sato H, Fujii M, Ichiura K, Kuwabara K, Nakamura Y. Low frequency of toothbrushing practices is an independent risk factor for diabetes mellitus in male and dyslipidemia in female: A large-scale, 5-year cohort study in Japan. J Cardiol. 2017:70(2):107-112.

17. Kuwabara M. Hyperuricemia, Cardiovascular Disease, and Hypertension. Pulse. 2016;3(3-4):242-52.

18. Kuwabara M, Motoki Y, Ichiura K, Fujii M, Inomata C, Sato H, Morisawa T, Morita Y, Kuwabara K, Nakamura Y. Association between toothbrushing and risk factors for cardiovascular disease: a large-scale, cross-sectional Japanese study. BMJ Open. 2016:6(1):e009870.

19. Kuwabara M, Yashiro M, Kotani K, Tsuboi S, Ae R, Nakamura Y, Yanagawa H, Kawasaki T. Cardiac Lesions and Initial Laboratory Data in Kawasaki Disease: a Nationwide Survey in Japan. J Epidemiol. 2015:25(3):189-193.

20. Kuwabara M, Niwa K, Nishi Y, Mizuno A, Asano T, Masuda K, Komatsu I, Yamazoe M, Takahashi O, Hisatome I，Relationship between serum uric acid levels and hypertension among Japanese individuals not treated for hyperuricemia and hypertension. Hypertens Res. 2014:37(8):785-9.

21. Hamada T*, Kuwabara M*, Watanabe A, Mizuta E, Ohtahara A, Omodani H, Watanabe M, Nakamura H, Hirota Y, Miyazaki S, Kato M, Ogino K, Kosaka H, Haruaki N, Taniguchi SI, Yamamoto K, Kotake H, Hisatome I. (*equally contributed) A comparative study on the effectiveness of losartan/hydrochlorothiazide and telmisartan/hydrochlorothiazide in patients with hypertension. Clin Exp Hypertens. 2014:36(4):251-7.

Co-author

22. Cicero AFG, Kuwabara M, Borghi C. A Critical Review of Nebivolol and its Fixed-Dose Combinations in the Treatment of Hypertension. Drugs. 2018 doi:10.1007/s40265-018-0999-y

23. Johnson RJ, Perez-Pozo PE, Lillo JL, Grases F, Schold JD, Kuwabara M, Sato Y, Andres-Hernando A, Garcia G, Jensen T, Rivard C, Sanchez-Lozada LG, Roncal C, Lanaspa MA. Fructose Increases Risk for Kidney Stones: Potential Role in Metabolic Syndrome and Heat Stress BMC Nephrol. 2018:19(1):315.

24. Kanbay M, Aslan G, Afsar B, Dagel T, Siriopol D, Kuwabara M, Incir S, Camkiran V, Rodriguez-Iturbe B, Lanaspa MA, Covic A, Johnson RJ. Acute effects of salt on blood pressure are mediated by serum osmolality. J Clin Hypertens (Greenwich). 2018:20(10):1447-1454.

25. Kimura K, Hosoya T, Uchida S, Inaba M, Makino H, Maruyama S, Ito S, Yamamoto T, Tomino Y, Ohno I, Shibagaki Y, Iimuro S, Imai N, Kuwabara M, Hayakawa H, Ohtsu H, Ohashi Y, FEATHER Study Investigators. Febuxostat Therapy for Patients with Stage 3 CKD and Asymptomatic Hyperuricemia: A Randomized Trial. Am J Kidney Dis. 2018. doi: 10.1053/j.ajkd.2018.06.028

26. Jespersen T, Kruse N, Mehta T, Kuwabara M, Noureddine L, Jalal D. Light wine consumption is associated with lower odds of cardiovascular disease in chronic kidney disease. Nutr Metab Cardiovasc Dis. 2018:269:334-338.

27. Milagres T, García-Arroyo FE, Lanaspa MA, Garcia G, Ishimoto T, Andres-Hernando A, Kuwabara M, Jensen T, Sato Y, Glaser J, Sánchez-Lozada LG, Johnson RJ, Roncal-Jimenez C. Rehydration with Fructose worsens Dehydration-induced Renal Damage. BMC Nephrol. 2018:19(1):180.

28. Bursill D, Taylor WJ, Terkeltaub R, Kuwabara M, Merriman TR, Grainger R, Pineda C, Louthrenoo W, Edwards NL, Andrés M, Vargas-Santos AB, Roddy E, Pascart T, Lin CT, Perez-Ruiz F, Tedeschi SK, Kim SC, Harrold LR, McCarthy G, Kumar N, Chapman PT, Tausche AK, Vazquez-Mellado J, Gutierrez M, Pinheiro GDRC, Richette P, Pascual E, Fisher MC, Burgos-Vargas R, Robinson PC, Singh JA, Jansen TL, Saag KG, Slot O, Uhlig T, Solomon DH, Keenan RT, Scire CA, Biernat-Kaluza E, Dehlin M, Nuki G, Schlesinger N, Janssen M, Stamp LK, Sivera F, Reginato AM, Jacobsson L, Lioté F, Ea HK, Rosenthal A, Bardin T, Choi HK, Hershfield MS, Czegley C, Choi SJ, Dalbeth N. Gout, Hyperuricemia and Crystal-Associated Disease Network (G-CAN) consensus statement regarding labels and definitions for disease elements in gout. Arthritis Care Res (Hoboken). 2018. doi: 10.1002/acr.23607.

29. Afsar B, Kuwabara M, Ortiz A, Yerlikaya A, Siriopol D, Covic A, Rodriguez-Iturbe B, Johnson R, Kanbay M. Salt Intake and Immunity. Hypertension. 2018:72(1):19-23.

30. Trostel J, Truong LD, Roncal-Jimenez CA, Miyazaki M, Miyazaki-Anzai S, Kuwabara M, McMahan RH, Andres-Hernando A, Sato Y, Jensen T, Lanaspa MA, Johnson RJ, Garcia GE. Different Effects of Global Osteopontin and Macrophage Osteopontin in Glomerular Injury. Am J Physiol Renal Physiol. 2018:315(4):F759-F768.

31. Bulbul MC, Dagel T, Afsar B, Ulusu NN, Kuwabara M, Covic A, Kanbay M. Disorders of Lipid Metabolism in Chronic Kidney Disease. Blood Purif. 2018:46(2):144-152.

32. Roncal-Jimenez CA, Sato Y, Milagres T, Andres-Hernando A, Garcia GE, Bjornstad P, Butler-Dawson J, Sorensen C, Newman L, Krisher L, Madero M, Glaser J, Garcia-Trabannino R, Jarquin-Romero E, Song Z, Jensen T, Kuwabara M, Rodriguez-Iturbe B, Sanchez-Lozada LG, Lanaspa MA, Johnson RJ. Experimental Heat Stress Nephropathy and Liver Injury are Improved by Allopurinol.Am J Physiol Renal Physiol. 2018:315(3):F726-F733

33. Cicero AFG, Kuwabara M, Johnson R, Bove M, Fogacci F, Rosticci M, Giovannini M, D'Addato S, Borghi C; Brisighella Heart Study group. LDL-oxidation, serum uric acid, kidney function and pulse-wave velocity: Data from the Brisighella Heart Study cohort. Int J Cardiol. 2018:261:204-208.

34. Lanaspa MA, Andres-Hernando A, Orlicky DJ, Cicerchi C, Jang C, Li N, Milagres T, Kuwabara M, Wempe MF, Rabinowitz JD, Johnson RJ, Tolan DR. Ketohexokinase C blockade ameliorates fructose-induced metabolic dysfunction in fructose-sensitive mice. J Clin Invest. 2018:128(6):2226-2238.

35. Tanno S, Yamamoto K, Kurata Y, Adachi M, Inoue Y, Otani N, Mishima, M, Yamamoto Y, Kuwabara M, Ogino K, Miake J, Haruaki N, Shirayoshi Y, Okada F, Yamamoto K, Hisatome, I. Protective effects of topiroxostat on an ischemia-reperfusion model of rat hearts. Circ J. 2018:82(4):1101-1111.

36. Jensen T, Abdelmalek MF, Sullivan S, Nadeau KJ, Green M, Roncal C, Nakagawa T, Kuwabara M, Sato Y, Kang DH, Tolan DR, Sanchez-Lozada LG, Rosen HR, Lanaspa MA, Diehl AM, Johnson RJ. Fructose and sugar: A major mediator of non-alcoholic fatty liver disease. J Hepatol. 2018:68(5):1063-1075.

37. Ikeda N, Nakazawa N, Kurata Y, Yaura H, Taufiq F, Minato H, Yoshida A, Ninomiya H, Nakayama Y, Kuwabara M, Shirayoshi Y, Hisatome I. Tbx18-positive cells differentiated from murine ES cells serve as proepicardial progenitors to give rise to vascular smooth muscle cells and fibroblasts. Biomed Res. 2017:38(4):229-238.

38. Yerlikaya A, Dagel T, King C, Kuwabara M, Lanaspa MA, Andres-Hernando A, Covic A, Manitius J, Sag AA, Kanbay M. Dietary and commercialized fructose: Sweet or sour? Int Urol Nephrol. 2017:49(9):1611-1620.

39. Roncal-Jimenez CA, Milagres T, Andres-Hernando A, Kuwabara M, Jensen T, Song Z, Bjornstad P, Garcia GE, Sato Y, Sanchez-Lozada LG, Lanaspa MA, Johnson RJ. The effects of exogenous desmopressin on a model of heat stress nephropathy in mice. Am J Physiol Renal Physiol. 2017:312(3):F418-F426.

40. Ae R, Kojo T, Kotani K, Okayama M, Kuwabara M, Makino N, Aoyama Y, Sano T, Nakamura Y. Differences in caregiver daily impression by sex, education and career length. Geriatr Gerontol Int. 2017:17(3):410-415.

41. Song Z, Roncal-Jimenez CA, Lanaspa-Garcia MA, Oppelt SA, Kuwabara M, Jensen T, Milagres T, Andres-Hernando A, Ishimoto T, Garcia GE, Johnson GC, MacLean PS, Sanchez-Lozada LG, Tolan DR, Johnson RJ. Role of Fructose and Fructokinase in Acute Dehydration Induced Vasopressin Gene Expression and Secretion in Mice. J Neurophysiol. 2016:311(4):F722-F730.

42. Ueno S, Hamada T, Taniguchi S, Ohtani N, Miyazaki S, Mizuta E, Ohtahara A, Ogino K, Yoshida A, Kuwabara M, Yoshida K, Ninomiya H, Kotake H, Taufiq F, Yamamoto K, Hisatome I. Effect of Antihypertensive Drugs on Uric Acid Metabolism in Patients with Hypertension: Cross-Sectional Cohort Study. Drug Res (Stuttg). 2016:66(12):628-632.

43. Roncal-Jimenez CA, Ishimoto T, Lanaspa MA, Milagres T, Hernando AA, Jensen T, Miyazaki M, Doke T, Hayasaki T, Nakagawa T, Marumaya S, Long DA, Garcia GE, Kuwabara M, Sánchez-Lozada LG, Kang DH, Johnson RJ. Aging-associated renal disease in mice is fructokinase dependent. Am J Physiol Renal Physiol. 2016:311(4):F722-F730.

44. Maharani N, Kuwabara M, Hisatome I. Hyperuricemia and Atrial Fibrillation. Int Heart J. 2016:57(4):395-9.

45. Mishima M, Hamada T, Maharani N, Ikeda N, Onohara T, Notsu T, Ninomiya H, Miyazaki S, Mizuta E, Sugihara S, Kato M, Ogino K, Kuwabara M, Hirota Y, Yoshida A, Otani N, Anzai N, Hisatome I. Effects of Uric Acid on the NO Production of HUVECs and its Restoration by Urate Lowering Agents. Drug Res (Stuttg). 2016:66(5):270-4.

46. Endo R, Kurata Y, Notsu T, Li P, Morikawa K, Kondo T, Ogura K, Miake J, Yoshida A, Shirayoshi Y, Ninomiya H, Higaki K, Kuwabara M, Yamamoto K, Inagaki Y, Hisatome I., Stabilization of Kv1.5 channel protein by the inotropic agent olprinone. Eur J Pharmacol. 2015:765:488-94.

47. Sugihara S, Hisatome I, Kuwabara M, Niwa K, Maharani N, Kato M, Ogino K, Hamada T, Ninomiya H, Higashi Y, Ichida K, Yamamoto K. Depletion of Uric Acid Due to SLC22A12 (URAT1) Loss-of-Function Mutation Causes Endothelial Dysfunction in Hypouricemia. Circ J. 2015:79(5):1125-32.

48. Yamamoto K, Yamamoto H, Yoshida K, Niwa K, Nishi Y, Mizuno A, Kuwabara M, Asano T, Sakoda K, Niinuma H, Nakahara F, Takeda K, Shindoh C, Komatsu Y. The Total Urine Protein-to-Creatinine Ratio Can Predict the Presence of Microalbuminuria. PLoS One. 2014:9(3):e91067.

49. Hosoya T, Kimura K, Itoh S, Inaba M, Uchida S, Tomino Y, Makino H, Matsuo S, Yamamoto T, Ohno I, Shibagaki Y, Iimuro S, Imai N, Kuwabara M, Hayakawa H. The effect of febuxostat to prevent a further reduction in renal function of patients with hyperuricemia who have never had gout and are complicated by chronic kidney disease stage 3: study protocol for a multicenter randomized controlled study. Trials. 2014:15(1):26.

50. Miyazaki S, Hamada T, Hirata S, Ohtahara A, Mizuta E, Yamamoto Y, Kuwabara M, Nosaka Y, Igawa O, Ogino K, Kato M, Yoshida A, Ninomiya H, Cheng J, Moriwaki Y, Yamamoto K, Hisatome I. Effects of azelnidipine on uric acid metabolism in patients with essential hypertension. Clin Exp Hypertens. 2014:36(7):447-53.

Editorial/ Letter/ Case

51. Kuwabara M. Letter by Kuwabara Regarding Article, “Assessment of Cardiovascular Risk in Older Patients With Gout Initiating Febuxostat Versus Allopurinol: Population-Based Cohort Study” Circulation 2018 In press

52. Kuwabara M, Hisatome I, Gender difference in the association between uric acid and atrial fibrillation. Circ J 2018. In press

53. Kuwabara M, Febuxostat does not increase all-cause mortality and cardiovascular mortality compared with placebo from FEATHER study. Arthritis & Rheumatology 2018. doi: 10.1002/art.40744

54. Kuwabara M, Kanbay M, Hisatome I. Uric Acid and Hypertension Because of Arterial Stiffness. Hypertension. 2018:72(3):582-584

55. Kuwabara M, Ishimura RN, Ishiwata S, Ohno M. Isolated Cardiac Sarcoidosis Presenting with Stroke. Korean Circ J. 2018:48(3):236-239.

56. Kuwabara M, Tanaka M. A Web Effect: Plummer-Vinson Syndrome. Am J Med. 2018:131(5):504-505.

57. Kuwabara M, Sato Y, Kanbay M, Johnson RJ. Uric Acid and Left Ventricular Hypertrophy: A Potentially New Modifiable Target? Am J Hypertens. 2017:30(3):229-231.

58. Hisatome I, Kuwabara M. Hyperuricemia Plays Pivotal Role in Progression of Kidney Disease. Circ J. 2016:80(8):1710-1.

59. Kotani K, Kuwabara M, Yamada T. Association between red blood cell parameters & atrial fibrillation after acute myocardial infarction. Indian J Med Res. 2015:141(3):358-9.