今月の研究者

伊豆津 宏二

伊豆津 宏二

2010年より虎の門病院血液内科に赴任し、主にリンパ腫の診療を担当しています。私が血液内科医を志した頃からリンパ腫の領域ではREAL分類、WHO分類などのリンパ腫の疾患分類が導入されました。我々が学生の頃には認識されていなかった疾患単位が数多く記載され、それをもとに治療法が議論されるようになりました。また、治療の面では抗CD20抗体リツキシマブなどの分子標的療法薬の導入により、少なくとも一部の病型については治癒率の改善がみられ、また複数の病型でquality of lifeの高い治療選択が可能となってきています。しかし、相変わらず難治性のリンパ腫や、どのような経過を辿るのかが分かっていない病型が少なくなく、診療の現場で治療方針を相談する際に患者さんを目の前にして説明に困ることが数多くあります。これらはいずれも私たちが臨床研究で解明していかなくてはいけないテーマであろうと思います。多くの患者さんの診療にあたっている医療機関の医師の責務として、これからの医療の進歩に寄与する研究を行い、それを発信していくことが極めて大事であると考えています。
リンパ腫の診療に関する長期的なテーマとしては、濾胞性リンパ腫未治療例の前向き観察研究(多施設共同研究)、体腔液リンパ腫の後方視研究(多施設共同研究)、アグレッシブリンパ腫に対する同種造血幹細胞移植における骨髄破壊的前処置の前向き研究(院内研究)などを行っています。また、若手の先生方と一緒に後方視研究を行ったり、他施設の研究者が主導する多施設共同研究にも参加しています。少しでもリンパ腫の診療の進歩に寄与できる研究をしようと心がけています。

発表・論文

2015年

Aoki T, Suzuki R, Kuwatsuka Y, Kako S, Fujimoto K, Taguchi J, Kondo T, Ohata K, Ito T, Kamoda Y, Fukuda T, Ichinohe T, Takeuchi K, Izutsu K, Suzumiya J. Long-term survival following autologous and allogeneic stem cell transplantation for blastic plasmacytoid dendritic cell neoplasm: A retrospective registry study from the Japan Society for Hematopoietic Cell Transplantation. Blood 2015; 125(23):3559-62

Yamamoto H, Uchida N, Matsuno N, Kon A, Nishida A, Ota H, Ikebe T, Nakano N, Ishiwata K, Araoka H, Takagi S, Tsuji M, Asano-Mori Y, Yamamoto G, Izutsu K, Masuoka K, Wake A, Yoneyama A, Makino S, Taniguchi S, Wake A, Yoneyama A, Makino S, Taniguchi S. I.v. BU/fludarabine plus melphalan or TBI in unrelated cord blood transplantation for high-risk hematological diseases.  Bone Marrow Transplant. 2015;50(4):607-9.

Kako S, Izutsu K, Kato K, Kim SW, Mori T, Fukuda T, Kobayashi N, Taji H, Hashimoto H, Kondo T, Sakamaki H, Morishima Y, Kato K, Suzuki R, Suzumiya J. The role of hematopoietic stem cell transplantation for relapsed and refractory Hodgkin Lymphoma. Am J Hematol 2015;90(2):132-8.

Maeda MH, Ohta H, Izutsu K, Shimizu J, Uesaka Y. Sporadic late-onset nemaline myopathy as a rare cause of slowly progressive muscle weakness with young adult onset.  Muscle Nerve. 2015;51(5):772-4

2014年

Akiyama S, Izutsu K, Ota Y, Imamura T, Ogawa O, Wake A, Takeuchi K. A case report of histologic transformation of primary follicular lymphoma of the duodenum. Medicine 2014;93(26)e165

Nakamoto-Matsubara R, Sakata-Yanagimoto M, Enami T, Yoshida K, Yanagimoto S, Shiozawa Y, Nanmoku T, Satomi K, Muto H, Obara N, Kato T, Kurita N, Yokoyama Y, Izutsu K, Ota Y, Sanada M, Shimizu S, Komeno T, Sato Y, Ito T, Kitabayashi I, Takeuchi K, Nakamura N, Ogawa S, Chiba S. Detection of the G17V RHOA Mutation in Angioimmunoblastic T-Cell Lymphoma and Related Lymphomas Using Quantitative Allele-Specific PCR. PLoS One. 2014 Oct 13;9(10):e109714

Aoki T, Izutsu K, Suzuki R, Nakaseko C, Arima H, Shimada K, Tomita A, Sasaki M, Takizawa J, Mitani K, Igarashi T, Maeda Y, Fukuhara N, Ishida F, Niitsu N, Ohmachi K, Takasaki H, Nakamura N, Kinoshita T, Nakamura S, Ogura M. Prognostic significance of pleural or peridardial effusion, and the implication of optimal treatment in primary mediastinal large B-cell lymphoma: a multicenter retrospective study in Japan. Haematologica 2014; 99(12):1817-25

Elsayed AA, Asano N, Ohshima K, Izutsu K, Kinoshita T, Nakamura S. Prognostic significance of CD20 expression and Epstein-Barr virus (EBV) association in classical Hodgkin lymphoma in Japan: A clinicopathologic study. Pathol Int. 2014;64(7):336-45.

Yamamoto H, Uchida N, Matsuno N, Ota H, Kageyama K, Wada S, Kaji D, Nishida A, Ishiwata K, Takagi S, Tsuji M, Asano-Mori Y, Yamamoto G, Izutsu K, Masuoka K, Wake A, Yoneyama A, Makino S, Taniguchi S. Anti-HLA Antibodies Other than Against HLA-A, -B, -DRB1 Adversely Affect Engraftment and Nonrelapse Mortality in HLA-Mismatched Single Cord Blood Transplantation: Possible Implications of Unrecognized Donor-specific Antibodies. Biol Blood Marrow Transplant. 2014; 20(10):1634-40

Izutsu K. Treatment of follicular lymphoma.. J Clin Exp Hematopathol. 2014;54(1):31-7

Takagi S, Araoka H, Uchida N, Uchida Y, Kaji D, Ota H, Nishida A, Ishiwata K, Tsuji M, Yamamoto H, Ito T, Matsuno N, Yamamoto G, Asano-Mori Y, Hayashi M, Izutsu K, Masuoka K, Wake A, Makino S, Yoneyama A, Taniguchi S. A prospective feasibility study of primary prophylaxis against invasive fungal disease with voriconazole following umbilical cord blood transplantation with fludarabine-based conditioning. Int J Hematol. 2014 May;99(5):652-8.

Chihara D, Izutsu K, Kondo E, Sakai R, Mizuta S, Yokoyama K, Kaneko H, Kato K, Hasegawa Y, Chou T, Sugahara H, Henzan H, Sakamaki H, Suzuki R, Suzumiya J. High-dose chemotherapy with autologous stem cell transplantation for elderly patients with relapsed/refractory diffuse large B-cell lymphoma: a nationwide retrospective study. Biol Blood Marrow Transplant. 2014; 20(5):684-9

Sakata-Yanagimoto M, Enami T, Yoshida K, Shiraishi Y, Ishii R, Miyake Y, Muto H, Tsuyama N, Sato-Otsubo A, Okuno Y, Sakata S, Kamada Y, Nakamoto-Matsubara R, Tran NB, Izutsu K, Sato Y, Ohta Y, Furuta J, Shimizu S, Komeno T, Sato Y, Ito T, Noguchi M, Noguchi E, Sanada M, Chiba K, Tanaka H, Suzukawa K, Nanmoku T, Hasegawa Y, Nureki O, Miyano S, Nakamura N, Takeuchi K, Ogawa S, Chiba S. Somatic RHOA mutation in angioimmunoblastic T cell lymphoma. Nat Genet. 2014;46(2):171-5

2013年

Sekiguchi Y, Matsuzawa N, Shimada A, Imai H, Wakabayashi M, Sugimoto K, Nakamura N, Sawada T, Izutsu K, Takeuchi K, Ohta Y, Komatsu N, Noguchi M. Angioimmunoblastic T-cell lymphoma with intramedullary production of platelet-derived growth factor and possibly complicating myelofibrosis: report of a case with review of the literature. Int J Hematol. 2013; 98(2):250-7

Kim SW, Yoon SS, Suzuki R, Matsuno Y, Yi HG, Yoshida T, Imamura M, Wake A, Miura K, Hino M, Ishikawa T, Kim JS, Maeda Y, Lee JJ, Kang HJ, Lee HS, Lee JH, Izutsu K, Fukuda T, Kim CW, Yoshino T, Ohshima K, Nakamura S, Nagafuji K, Suzumiya J, Harada M, Kim CS.  Comparison of outcomes between autologous and allogeneic hematopoietic stem cell transplantation for peripheral T-cell lymphomas with central review of pathology. Leukemia. 2013;27(6):1394-7.

Sakamoto K, Nakasone H, Tsurumi S, Sasaki K, Mitani K, Kida M, Hangaishi A, Usuki K, Kobayashi A, Sato K, Karasawa-Yamaguchi M, Izutsu K, Okoshi Y, Chiba S, Kanda Y. Prednisone versus high-dose dexamethasone for untreated primary immune thrombocytopenia. A retrospective study of the Japan Hematology & Oncology Clinical Study Group. J Thromb Thrombolysis. 2014;37(3):279-86

Ishii M, Yamaguchi Y, Yakabe M, Ohike Y, Eto M, Izutsu K, Hangaishi A, Akishita M, Kurokawa M, Ouchi Y. Intravascular large B-cell lymphoma with symptoms resembling progressive dementia: a clinical case report. J Am Geriatr Soc. 2013;61:303-4.

Matsuno N, Yamamoto H, Watanabe N, Uchida N, Ota H, Nishida A, Ikebe T, Ishiwata K, Nakano N, Tsuji M, Asano-Mori Y, Izutsu K, Masuoka K, Wake A, Yoneyama A, Nakauchi H, Taniguchi S. Rapid T-cell chimerism switch and memory T-cell expansion are associated with pre-engraftment immune reaction early after cord blood transplantation. Br J Haematol. 2013;160:255-8

Sugaya M, Hamada T, Kawai K, Yonekura K, Ohtsuka M, Shimauchi T, Tokura Y, Nozaki K, Izutsu K, Suzuki R, Setoyama M, Nagatani T, Koga H, Tani M, Iwatsuki K. Guidelines for the management of cutaneous lymphomas (2011): A consensus statement by the Japanese Skin Cancer Society - Lymphoma Study Group. J Dermatol. 2013;40:2-14

2012年

Ito Y, Kimura H, Maeda Y, Hashimoto C, Ishida F, Izutsu K, Fukushima N, Isobe Y, Takizawa J, Hasegawa Y, Kobayashi H, Okamura S, Kobayahi H, Yamaguchi M, Suzumiya J, Hyo R, Nakamura S, Kawa K, Oshimi K, Suzuki R. Pretreatment EBV-DNA copy number is predictive of response and toxicities to SMILE chemotherapy for extranodal NK/T-cell lymphoma, nasal type. Clin Cancer Res. 2012;18:4183-4190

Araoka H, Fujii T, Izutsu K, Kimura M, Nishida A, Ishiwata K, Nakano N, Tsuji M, Yamamoto H, Asano-Mori Y, Uchida N, Taniguchi S, Yoneyama A. Rapidly progressive fatal hemorrhagic pneumonia caused by Stenotrophomonas maltophilia in hematological malignancy. Transpl Infect Dis; 2012;14:355-363

Kimura M, Araoka H, Ucnida N, Ohno H, Miyazaki Y, Fujii T, Nishida A, Izutsu K, Wake A, Taniguchi S, Yoneyama A. Cunninghamella bertholletiae pneumonia showing a reversed halo sign on chest computed tomography scan following cord blood transplantation. Med Mycol 2012;50:412-426

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