今月の研究者

林 伸和

林 伸和

1)(キャリア)
1989年東京大学医学部卒業後、同大学皮膚科学教室に入局、1990年に日本赤十字社医療センター、1995年に関東逓信病院(現NTT東日本関東病院)にそれぞれ1年半出向し臨床病院での診療経験を積みました。また,1993年米国マイアミ大学細胞生物学教室に留学し,結合組織成長因子の遺伝子発現制御の研究で東京大学の学位を取得しました。2000年に東京女子医科大学皮膚科講師,2006年から助教授(その後准教授に改称),2011年に虎の門病院皮膚科部長となり,現在に至っています。日本皮膚科学会代議員,日本臨床皮膚科医会常任理事,日本美容皮膚科学会理事,日本香粧品学会副理事長,日本レーザー医学会評議員,日本皮膚悪性腫瘍学会評議員などの学会活動を務めています.

2)研究分野
にきび(尋常性ざ瘡)や化膿性汗腺炎といった毛包脂腺系疾患の臨床を専門としています。新しい薬剤の臨床試験のほか,他施設との共同研究でヒト不死化脂腺細胞株の樹立や、ざ瘡における薬剤耐性菌の調査を行っています。現在,日本皮膚科学会の尋常性痤瘡治療ガイドライン改訂委員会委員長を務めていますが,エビデンスのある新しい治療やスキンケアを標準化し,それを普及させることを目標にしています.学校保健活動を通じて中高生への疾患啓発を行ったり,日本痤瘡研究会を設立して研究推進の場を作ったりしています.

3)今後の抱負、アピール
皮膚科の疾患は生命予後に関係しないことが多く,医学的な根拠のない治療やスキンケアが漫然と行われています.しかし症状が目に見えるため,quality of life(生活の質)に大きな影響を与えます.個々のエビデンスの確立に注力し,最善の医療とスキンケアが実践できることを目標にして臨床研究を進めています.

発表・論文

4) 発表・論文(虎の門病院赴任以降上梓された論文)

1. Aoki S, Nakase K, Hayashi N, Noguchi N:Transconjugation of erm(X) conferring high-level resistance of clindamycin for Cutibacterium acnes. J Med Microbiol. 2019 Jan;68(1):26-30.

2. Nakase K, Yoshida A, Saita H, Hayashi N, Nishijima S, Nakaminami H, Noguchi N:Relationship between quinolone use and resistance of Staphylococcus epidermidis in patients with acne vulgaris. J Dermatol. 2019 Sep;46(9):782-786.

3. Morita A, Takahashi H, Ozawa K, Imafuku S, Nakama T, Takahashi K, Matsuyama T, Okubo Y, Kitamura S, Matsuda N, Zhao Y, Yokoyama M, Hayashi N, Terui T:Twenty‐four‐week interim analysis from a phase 3 open‐label trial of adalimumab in Japanese patients with moderate to severe hidradenitis suppurativa. J Dermatol. 2019 Sep;46(9):745-751.

4. Tanizaki H, Tanioka M, Yamashita, Hayashi N:Quantitative evaluation of atrophic acne scars using 3D image analysis with reflected LED light. Skin Res Technol, 2019 Sep 2,20-24,doi: 10.1111/srt.12756.

5. Thiboutot DM, Dréno B, Abanmi A, Alexis AF, Araviiskaia E, Barona Cabal MI, Bettoli V, Casintahan F, Chow S, da Costa A1, El Ouazzani T, Goh CL, Gollnick HPM, Gomez M, Hayashi N, Herane MI, Honeyman J, Kang S, Kemeny L, Kubba R, Lambert J, Layton AM, Leyden JJ, López-Estebaranz JL, Noppakun N, Ochsendorf F, Oprica C, Orozco B, Perez M, Piquero-Martin J, See JA, Suh DH, Tan J, Lozada VT, Troielli P, Xiang LF:Practical management of acne for clinicians: An international consensus from the Global Alliance to Improve Outcomes in Acne. J Am Acad Dermatol. 2018 Feb;78(2S1):S1-S23.

6. See JA, Goh CL, Hayashi N, Suh DH, Casintahan FA:Optimizing the use of topical retinoids in Asian acne patients. J Dermatol. 2018 May;45(5):522-528.

7. Hayashi N, Akamatsu H, Iwatsuki K, Shimada-Omori R, Kaminaka C, Kurokawa I, Kono T, Kobayashi M, Tanioka M, Furukawa F, Furumura M, Yamasaki O, Yamasaki K, Yamamoto Y, Miyachi Y, Kawashima M:Japanese Dermatological Association Guidelines: Guidelines for the treatment of acne vulgaris 2017. J Dermatol, 2018 :Aug;45(8):898-935.

8. Hayashi N, Kurokawa I, Siakpere O, Endo A, Hatanaka T, Yamada M, Kawashima M: Clindamycin phosphate 1.2%/benzoyl peroxide 3% fixed-dose combination gel versus topical combination therapy of adapalene 0.1% gel and clindamycin phosphate 1.2% gel in the treatment of acne vulgaris in Japanese patients: A multicenter, randomized, investigator-blind, parallel-group study. J Dermatol, 2018:Aug;45(8);951-962.

9. Nakase K, Nakaminami H, Takenaka Y, Hayashi N, Kawashima M, Noguchi N:Propionibacterium acnes is developing gradual increase in resistance to oral tetracyclines. J Med Microbiol. 2017 Jan;66(1):8-12.

10. Oshima Y,Hoshino J,Suwabe T,Hayami N,Yamanouchi M Sekine ,Ueno T,Mizuno H,Yabuuchi J,Imafuku A,Kawada M,Hiramatsu ,Hasegawa E,Sawa N,Takaichi K,Hayashi ,Fujii T,Ubara Y:Multicentric Castleman's disease associated with IgA vasculitis (Henoch-Schönlein purpura) responding well to tocilizumab: a case report.Clin Rheumato,2017 Mar;36(3):729-733.

11. Kawashima M, Sato S, Furukawa F, Matsunaga K, Akamatsu H, Igarashi A, Tsunemi Y, Hayashi N, Yamamoto Y, Nagare T, Katsuramaki T:Twelve-week, multicenter, placebo-controlled, randomized, double-blind, parallel-group, comparative phase II/III study of benzoyl peroxide gel in patients with acne vulgaris: A secondary publication.J Dermatol,2017 Jul;44(7):774-782.

12. Kaneko T, Sasaki S, Baba N, Koh K, Matsui K, Ohjimi H , Hayashi N, Nakano A, Ohki K, Kuwano Y, Morimoto A, Tamaki Z, Kakazu M, Kishi K, Oyama T, Sato A, Kato R, Higuchi T:Efficacy and safety of oral propranolol for infantile hemangioma in Japan.Pediatrics International,2017 Aug;59(8):869-877.

13. Nakase K, Hayashi N, Akiyama Y, Aoki S, Noguchi N:Antimicrobial susceptibility and phylogenetic analysis of Propionibacterium acnes isolated from acne patients in Japan between 2013 and 2015. J Dermatol,2017 Nov;44(11):1248-1254.

14. Abad-Casintahan F, Chow SK, Goh CL, Kubba R, Hayashi N, Noppakun N, See J, Suh DH, Xiang LH, Kang S;Asian Acne Board:Frequency and characteristics of acne-related post-inflammatory hyperpigmentation.J Dermatol,2016 Jul;43(7):826-828.

15. Nakase K, Nakaminami H, Takenaka Y, Hayashi N, Kawashima M, Noguchi N:A novel 23S rRNA mutation in Propionibacterium acnes confers resistance to 14-membered macrolides.Journal of Global Antimicrobial Resistance,6:160-161,2016.

16. Nemoto O, Hayashi N, Kitahara Y, Furue M, Hojo S, Nomoto M, Shima S; Japanese E6005 Study Investigators:Effect of topical phosphodiesterase 4 inhibitor E6005 on Japanese children with atopic dermatitis: Results from a randomized, vehicle-controlled exploratory trial.Journal of Dermatology ,J Dermatol,2016 Aug;43(8):881-887

17. Hayashi N, Miyachi Y, Kawashima M:Prevalence of scars and "mini-scars", and their impact on quality of life in Japanese patients with acne.J Dermatol,2015 Jul;42(7):690-696.

18. Kurokawa I, Hayashi N; Japan Acne Research Society:Questionnaire surveillance of hidradenitis suppurativa in Japan.J Dermatol,2015 Jul;42(7):747-749.

19. Nakamura Y, Ohara K, Kishi A, Teramoto Y, Sato S, Fujisawa Y, Fujimoto M, Otsuka F, Hayashi N, Yamazaki N, Yamamoto A:Effects of non-amputative wide local excision on the local control and prognosis of in situ and invasive subungual melanoma.J Dermatol,2015 Sep;42(9):861-866

20. Kishi A, Hayashi N:Biphasic skin reactions during telaprevirbased therapy of Japanese patients infected with hepatitis C virus. J Am Acad Dermatol, 2014 March;70(3):584-586.

21. Furue M,Kitahara Y,Akama H,Hojo S,Hayashi N,Nakagawa H,The JAPANESE E6005 Study Investigators:Safety and efficacy of topical E6005, a phosphodiesterase 4 inhibitor, in Japanese adult patients with atopic dermatitis: Results of a randomized, vehicle-controlled, multicenter clinical trial. Journal of dermatology 2014;41:577-585

22. Hayashi N, Kawashima M:Study of the usefulness of moisturizers on adherence of acne patients treated with adapalene. J Dermatol. 2014;41:592-597

23. Nakase K, Nakaminami H, Takenaka Y, Hayashi N, Kawashima M, Noguchi N:Relationship between the severity of acne vulgaris and antimicrobial resistance of bacteria isolated from acne lesions in a hospital in Japan.J Med Microbiol. 2014 May;63(Pt 5):721-728

24. Shiomi T, Noguchi T, Nakayama H, Yoshida Y, Yamamoto O, Hayashi N, Ohara K.Clinicopathological study of invasive extramammary Paget's disease: subgroup comparison according to invasion depth. J Eur Acad Dermatol Venereol. 2013 May;27(5):589-92.

25. Namba M, Hayashi N, Takenaka Y, Kawashima M.: Multiple basal cell carcinomas in an atomic bomb survivor. Int J Dermatol. 2013 May;52(5):605-607.

26. Sato T, Akimoto N, Kitamura K, Kurihara H, Hayashi N, Ito A.: Adapalene suppresses sebum accumulation via the inhibition of triacylglycerol biosynthesis and perilipin expression in differentiated hamster sebocytes in vitro. J Dermatol Sci. 2013 Jun;70(3):204-210.

27. Takenaka Y, Hoshino Y, Nakajima H, Hayashi N, Kawashima M, Imokawa G.: Paracrine cytokine mechanisms underlying the hyperpigmentation of seborrheic keratosis in covered skin areas. J Dermatol. 2013 Jul;40(7):533-42.

28. Takenaka Y, Hayashi N, Takeda M, Ashikaga S, Kawashima M.: Glycolic acid chemical peeling improves inflammatory acne eruptions through its inhibitory and bactericidal effects on Propionibacterium acnes. J Dermatol. 2012 Apr;39(4):350-4.

29. Yamamoto Y, Funasaka Y, Matsunaga K, Akita H, Ueda S, Usuki A, Kikuchi K, Kono T, Tanaka T, Hayashi N, Moroi Y, Yonei N, Furukawa F:Guidelines for chemical peeling in Japan (3rd edition). J Dermatol. 2012 Apr;39(4):321-325.

30. Hayashi N, Kawashima M :Efficacy of oral antibiotics on acne vulgaris and their effects on quality of life: a multicenter randomized controlled trial using minocycline, roxithromycin and faropenem. J Dermatol. 2011 Feb;38(2):111-9.

31. Abad-Casintahan MF, Chow SKE, Goh CL, Hayashi N, Kubba R, Suh DH, Wu Y: Epidemiology and treatment of acne in Asia. In Asian Skin and Skin Diseases. Eun HC, Kim SC, Lee WS ed. pp201-210, Medrang Inc., Seoul, 2011

32. Hayashi N, Kawashima M: Multicenter randomized controlled trial on combination therapy with 0.1% adapalene gel and oral antibiotics for acne vulgaris: Comparison of the efficacy of adapalene gel alone and in combination with oral faropenem. J Dermatol. 2012 Jun; 39(6):511-515.

33. Miyachi Y, Hayashi N, Furukawa F, Akamatsu H, Matsunaga K, Watanabe S, Kawashima M.: Acne management in Japan: study of patient adherence. Dermatology. 2011;223(2):174-81.

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