今月の研究者

大倉 遊

大倉 遊

〇キャリア
2009年に産業医科大学を卒業後、外科初期研修医として虎の門病院へ入職いたしました。外科初期研修医、後期研修医と修練をつみ、2014年に上部消化器外科の医員となりました。2016年には東京医科歯科大学大学院 医歯学総合研究科へ入学し、臨床の傍ら、大学院へも通いながら研究を行ない、2020年3月食道癌患者に対する治療介入が与える精神的ストレスと周術期QOLについての研究で学位取得いたしました。2019年には日本の食道癌手術患者10826例のデータを用いた食道癌術後合併症のリスクモデルについての論文も執筆させていただきました。また日本臨床腫瘍研究グループ(JCOG)にも積極的に参加し、症例登録を行なっております。食道癌を中心に、多くの臨床研究に従事し、学会発表や論文報告も多数行なってまいりました。それらが評価され、2019年度 日本消化器外科学会学会賞(JSGS Young Investigator of the Year 2019)を受賞することができました。
現在は、日本外科専門医、日本食道学会食道外科専門医、日本消化器外科専門医・指導医、日本内視鏡外科学会技術認定医・評議員 などを務めております。

〇研究分野
食道癌の集学的治療(栄養管理、化学療法・放射線療法のリスク、副作用低減等)
食道癌外科治療(胸管切除の意義、リンパ節郭清範囲、術後合併症メカニズム、合併症低減の取り組み等)
食道癌転移病巣に対する治療
胃癌の外科治療 など

〇今後の抱負
食道癌患者の治療を行なう中で生じる疑問に対し、臨床データをもとに、それらの疑問を解決する形で研究を進めてまいりました。今後も、常に臨床を第一に考え、実臨床に直結できる研究を目指して日々精進してまいります。単施設研究はもちろん、多施設共同研究も積極的に行い、新たなエビデンス構築を行なっていく所存です。

発表・論文

〇発表・論文

論文 (First Authorのみ)

1. Yu Ohkura, Masaki Ueno, Toshiro Iizuka, Harushi Udagawa. Effectiveness of lymphadenectomy along the thoracic duct for radical esophagectomy. 2021 Jul 31. doi: 10.1007/s10388-021-00868-4. Online ahead of print.

2. Yu Ohkura, Masaki Ueno, Harushi Udagawa. Advantageous factors of R0 curative conversion esophagectomy and the optimal extent of lymphadenectomy after induction therapy for cT4b thoracic esophageal cancer. Ann Gastroenterol Surg. 2020 Dec 11;5(2):204-214.

3. Yu Ohkura, Junichi Shindoh, Kanako Ichikura, Harushi Udagawa, Masaki Ueno, Eisuke Matsushima. Perioperative risk factors of psychological distress in patients undergoing treatment for esophageal cancer. World J Surg Oncol. 2020 Dec 9;18(1):326.

4. Yu Ohkura. ASO Author Reflections: Effectiveness of Resection of Oligometastases from Esophageal Cancer. Ann Surg Oncol. 2020 Mar;27(3):660-661.

5. Yu Ohkura, Junichi Shindoh, Masaki Ueno, Toshiro Iizuka, Harushi Udagawa. Clinicopathologic Characteristics of Oligometastases from Esophageal Cancer and Long-Term Outcomes of Resection. Ann Surg Oncol. 2020 Mar;27(3):651-659.

6. Yu Ohkura, Kanako Ichikura, Junichi Shindoh, Masaki Ueno, Harushi Udagawa, Eisuke Matsushima. Relationship between psychological distress and health-related quality of life at each point of the treatment of esophageal cancer Esophagus. 2020 Jul;17(3):312-322.

7. Yu Ohkura, Hiroaki Miyata, Hiroyuki Konno, Harushi Udagawa, Masaki Ueno, Junichi Shindoh, Hiraku Kumamaru, Go Wakabayashi, Mitsukazu Gotoh, Masaki Mori. Development of a model predicting the risk of eight major postoperative complications after esophagectomy based on 10 826 cases in the Japan National Clinical Database J Surg Oncol. 2019 Dec 10. doi: 10.1002/jso.25800. Online ahead of print.

8. Yu Ohkura, Masaki Ueno, Harushi Udagawa. Risk factors for febrile neutropenia and effectiveness of primary prophylaxis with pegfilgrastim in patients with esophageal cancer treated with docetaxel, cisplatin, and 5-fluorouracil. World J Surg Oncol. 2019 Jul 17;17(1):125.

9. Yu Ohkura, Masaki Ueno, Toshiro Iizuka, Harushi Udagawa. Prognostic Factors and Appropriate Lymph Node Dissection in Salvage Esophagectomy for Locally Advanced T4 Esophageal Cancer. Ann Surg Oncol. 2019 Jan;26(1):209-216.

10. Y Ohkura, M Ueno, J Shindoh, T Iizuka, H Udagawa. Randomized controlled trial on efficacy of oligomeric formula (HINE E-GEL®) versus polymeric formula (MEIN®) enteral nutrition after esophagectomy for esophageal cancer with gastric tube reconstruction Dis Esophagus. 2019 May 1;32(5):doy084.

11. Yu Ohkura. ASO Author Reflections: Esophagectomy Versus Nonsurgical Treatment for Resectable Esophageal Cancer. Ann Surg Oncol. 2018 Dec;25(Suppl 3):703-704.

12. Yu Ohkura. ASO Author Reflections: Postoperative Chylothorax After Radical Subtotal Esophagectomy. Ann Surg Oncol. 2018 Dec;25(Suppl 3):705-706.

13. Yu Ohkura, Masaki Ueno, Junichi Shindoh, Toshiro Iizuka, Hairin Ka, Harushi Udagawa. Risk Factors for Postoperative Chylothorax After Radical Subtotal Esophagectomy. Ann Surg Oncol. 2018 Sep; 25(9): 2739-2746.

14. Yu Ohkura, Junichi Shindoh, Masaki Ueno, Toshiro Iizuka, Harushi Udagawa. Comparison of Outcome of Esophagectomy Versus Nonsurgical Treatment for Resectable Esophageal Cancer with Clinical Complete Response to Neoadjuvant Therapy. Ann Surg Oncol. 2018. Aug;25 (8): 2428-2433.

15. Yu Ohkura, Masaki Ueno, Toshiro Iizuka, Harushi Udagawa. Effectiveness of etilefrine regimen for chylothorax after esophagectomy with thoracic duct resection Esophagus. 2018; 15(1): 33-38.

16. Yu Ohkura, Junichi Shindoh, Masaki Ueno, Toshiro Iizuka, Shusuke Haruta, Harushi Udagawa. A new postoperative pain management (intravenous acetaminophen: Acelio®) leads to enhanced recovery after esophagectomy: a propensity score-matched analysis. Surg Today. 2018 May; 48(5): 502-509.

17. Yu Ohkura, Shusuke Haruta, Junichi Shindoh, Tsuyoshi Tanaka, Masaki Ueno, Harushi Udagawa. Efficacy of prophylactic splenectomy for proximal advanced gastric cancer invading greater curvature. World J Surg Oncol. 2017 May 25; 15(1): 106.

18. Yu Ohkura, Shusuke Haruta, Yusuke Maeda, Masaki Ueno, Harushi Udagawa. Delayed traumatic diaphragmatic hernia with bacterial pleuritis. Int. Surg. 2017 101: 270-274.

19. Yu Ohkura, Shusuke Haruta, Junichi Shindoh, Tsuyoshi Tanaka, Masaki Ueno, Harushi Udagawa. Effectiveness of postoperative intravenous acetaminophen (Acelio) after gastrectomy: A propensity score-matched analysis. Medicine (Baltimore). 2016 Nov; 95(44): e5352.

20. Yu Ohkura, Shusuke Haruta, Tsuyoshi Tanaka, Masaki Ueno, Harushi Udagawa. Effectiveness of postoperative elemental diet (Elental®) in elderly patients after gastrectomy. World J Surg Oncol. 2016 Oct 19;14(1):268.

21. Yu Ohkura, Masaki Ueno, Toshiro Iizuka, Shusuke Haruta, Tsuyoshi Tanaka, Harushi Udagawa. Factors Predicting Effectiveness of Neoadjuvant Therapy for Esophageal Squamous Cell Carcinoma. Medicine (Baltimore). 2016 Apr; 95(15): e3365.

22. Yu Ohkura, Hisashi Shinohara, Junichi Shindoh, Shusuke Haruta, Masaki Ueno, Yoshiharu Sakai, Harushi Udagawa. A New Scoring System Using Preoperative Factors and Contour Mapping for Predicting Postoperative Complications of Laparoscopic Gastrectomy. Dig Surg. 2016; 33(1): 74-81.

23. Yu Ohkura, Junichi Shindoh, Shusuke Haruta, Daisuke Kaji, Yasunori Ota, Takeshi Fujii, Masaji Hashimoto, Goro Watanabe, Masamichi Matsuda. Primary Adrenal Lymphoma Possibly Associated With Epstein-Barr Virus Reactivation Due to Immunosuppression Under Methotrexate Therapy. Medicine (Baltimore). 2015 Aug; 94(31): e1270.

24. Yu Ohkura, Kazunari Sasaki, Masamichi Matsuda, Masaji Hashimoto, Goro Watanabe. Long-term prognosis after resection of cryptogenic hepatocellular carcinoma. BMC Surg. 2015 Oct 17;15:115.

25. Yu Ohkura, Hisashi Shinohara, Shusuke Haruta, Masaki Ueno, Masaji Hashimoto, Yoshiharu Sakai, Harushi Udagawa. Hepatectomy Offers Superior Survival Compared with Non-surgical Treatment for ≤ 3 Metastatic Tumors with Diameters < 3 cm from Gastric Cancer: A Retrospective Study. World J Surg. 2015 Nov; 39(11): 2757-63.

26. Yu Ohkura, Shusuke Haruta, Hisashi Shinohara, Seigi Lee, Yudai Fukui, Nao Kobayashi, Kota Momose, Masaki Ueno, Harushi Udagawa. Laparoscopic plug removal for femoral nerve colic pain after mesh & plug hernioplasty. BMC Surg. 2015 May 17;15:64.

27. Yu Ohkura, Kazunari Sasaki, Masamichi Matsuda, Masaji Hashimoto, Takeshi Fujii, Goro Watanabe. Pancreatic cancer accompanied by a moderate-sized pseudocyst with extrapancreatic growth. BMC Med Imaging. 2015 May 7;15:14.

28. Yu Ohkura, Seigi Lee, Daisuke Kaji, Yasunori Ota, Shusuke Haruta, Yasuaki Takeji, Hisashi Shinohara, Masaki Ueno, Harushi Udagawa. Spontaneous perforation of primary gastric malignant lymphoma: a case report and review of the literature. World J Surg Oncol. 2015 Feb 8;13:35.

29. Yu Ohkura, Masaji Hashimoto, Seigi Lee, Kazunari Sasaki, Masamichi Matsuda, Goro Watanabe. Right hepatectomy for giant cavernous hemangioma with diffuse hemangiomatosis around Glisson's capsule. World J Gastroenterol. 2014 Jul 7; 20(25): 8312-6.

30. Yu Ohkura, Masaji Hashimoto, Kazunari Sasaki, Goro Watanabe. Complete acute gallbladder torsion diagnosed with abdominal ultrasonography and colour Doppler imaging. BMJ Case Rep. 2013 Mar 14;2013:bcr2012008460.

31. Yu Ohkura, Kazunari Sasaki, Masamichi Matsuda, Masaji Hashimoto. Total pancreatectomy for recurrent intraductal papillary mucinous carcinoma in remnant pancreas of pancreaticoduodenectomy for intraductal papillary mucinous adenocarcinoma. BMJ Case Rep. 2013 May 23;2013:bcr2013009856.

32. Yu Ohkura, Toshiro Iizuka, Daisuke Kikuchi, Satoshi Yamashita, Masanori Nakamura, Akira Matsui, Toshifumi Mitani, Shu Hoteya, Mitsuru Kaise, Naohisa Yahagi. Endoscopic submucosal dissection for early esophageal cancer associated with achalasia. Turk J Gastroenterol. 2013; 24(2): 161-6..

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